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  • 1.  NJM - ? Help with Leber’s?

    Posted 07-30-2025 19:23
    

    Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease

    Authors: Louise A. Hyslop, Ph.D. https://orcid.org/0000-0002-0326-7208, Emma L. Blakely, Ph.D., Magomet Aushev, Ph.D. https://orcid.org/0000-0002-1348-6404, Jordan Marley, Ph.D., YukoTakeda, Ph.D., Angela Pyle, Ph.D., Eilis Moody, M.Sc., +23 , and Mary Herbert, Ph.D.Author Info & Affiliations
    Published July 16, 2025
    N Engl J Med 2025;393:438-449
    DOI: 10.1056/NEJMoa2415539







    Edward M. Cohn, MD, mba, mph
    3535 W. 13 Mile (506)
    Royal Oak, MI 48073
    Ph: 248-551-8282
    Fax: 248-551-9085


  • 2.  RE: NJM - ? Help with Leber’s?

    Posted 07-30-2025 23:59
    I read that as well - could potentially eradicate it but will take generations. 
    Sent from my iPhone - sorry for any crazy autocorrect errors 



    Original Message


  • 3.  RE: NJM - ? Help with Leber’s?

    Posted 07-31-2025 10:51
    Great long term solution as it permanently solves the inheritance problem.  But there are some unresolved risks related to mitochondrial / nuclear communications that may or may not be problematic (I await with bated breath).

    But note that this was done in the UK. Patrick Yu Wai Man in on top of this.  This is not an issue for us in the US. This is "genetic engineering" and is illegal and would never be approved by IRB or NIH in the US.  This was made eminently clear when Valerio and I broached the subject about 20 years ago.  

    --Alfredo




    Original Message


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