NANOSNET

Dear NANOS group

I have a 16yo F  with TED and progressive proptosis and CAS 5

-mild enlargement of eoms but mostly fat enlargement 

She wants to have teprotumumab but not approved due to age

What other options other than IV steroids? Which still not optimal due to age

Are any of the current study trials accepting 16yo pt?

Thank you for your guidance 

Claudia 

This is tough. You could try steroids via eugogo dosing. 500 mg iv weekly for 4 or 6 weeks and if it works additional 4-6 weeks .

Teprotumumab can also be given if insurance can authorize 

Clinical trials will likely not recruit under 18

Orbital radiation is an option although best to try one of the above first 

Madhura

Dear NANOS group

I have a 16yo F  with TED and progressive proptosis and CAS 5

-mild enlargement of eoms but mostly fat enlargement 

She wants to have teprotumumab but not approved due to age

What other options other than IV steroids? Which still not optimal due to age

Are any of the current study trials accepting 16yo pt?

Thank you for your guidance 

Claudia 

This is tough. You could try steroids via eugogo dosing. 500 mg iv weekly for 4 or 6 weeks and if it works additional 4-6 weeks .

Teprotumumab can also be given if insurance can authorize 

Clinical trials will likely not recruit under 18

Orbital radiation is an option although best to try one of the above first 

Madhura

Dear NANOS group

I have a 16yo F  with TED and progressive proptosis and CAS 5

-mild enlargement of eoms but mostly fat enlargement 

She wants to have teprotumumab but not approved due to age

What other options other than IV steroids? Which still not optimal due to age

Are any of the current study trials accepting 16yo pt?

Thank you for your guidance 

Claudia 

This is tough. You could try steroids via eugogo dosing. 500 mg iv weekly for 4 or 6 weeks and if it works additional 4-6 weeks .

Teprotumumab can also be given if insurance can authorize 

Clinical trials will likely not recruit under 18

Orbital radiation is an option although best to try one of the above first 

Madhura

Dear NANOS group

I have a 16yo F  with TED and progressive proptosis and CAS 5

-mild enlargement of eoms but mostly fat enlargement 

She wants to have teprotumumab but not approved due to age

What other options other than IV steroids? Which still not optimal due to age

Are any of the current study trials accepting 16yo pt?

Thank you for your guidance 

Claudia 

This is tough. You could try steroids via eugogo dosing. 500 mg iv weekly for 4 or 6 weeks and if it works additional 4-6 weeks .

Teprotumumab can also be given if insurance can authorize 

Clinical trials will likely not recruit under 18

Orbital radiation is an option although best to try one of the above first 

Madhura

Dear NANOS group

I have a 16yo F  with TED and progressive proptosis and CAS 5

-mild enlargement of eoms but mostly fat enlargement 

She wants to have teprotumumab but not approved due to age

What other options other than IV steroids? Which still not optimal due to age

Are any of the current study trials accepting 16yo pt?

Thank you for your guidance 

Claudia 

This is tough. You could try steroids via eugogo dosing. 500 mg iv weekly for 4 or 6 weeks and if it works additional 4-6 weeks .

Teprotumumab can also be given if insurance can authorize 

Clinical trials will likely not recruit under 18

Orbital radiation is an option although best to try one of the above first 

Madhura

Dear NANOS group

I have a 16yo F  with TED and progressive proptosis and CAS 5

-mild enlargement of eoms but mostly fat enlargement 

She wants to have teprotumumab but not approved due to age

What other options other than IV steroids? Which still not optimal due to age

Are any of the current study trials accepting 16yo pt?

Thank you for your guidance 

Claudia 

Dear NANOS group

I have a 16yo F  with TED and progressive proptosis and CAS 5

-mild enlargement of eoms but mostly fat enlargement 

She wants to have teprotumumab but not approved due to age

What other options other than IV steroids? Which still not optimal due to age

Are any of the current study trials accepting 16yo pt?

Thank you for your guidance 

Claudia