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  • 1.  rhNGF study for NAION

    Posted 12 days ago
    Does anyone know if this study drug is promising from a mechanistic perspective? I am interested in site participation but curious how promising it is. I'm sure some of you research leaders are involved in it so curious about your wisdom thus far.

     

    On behalf of Dompé Farmaceutici S.p.A, Parexel would like to invite you to participate in a Phase 3 study on NAION; A Randomized, Multicenter, Vehicle-Controlled, Double-Masked, Phase 3 Clinical Study to Evaluate the Safety and Efficacy of Intranasal Cenegermin-bkbj (Recombinant Human Nerve Growth Factor [rhNGF]) in Participants with Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) | NGF-NAION-301 

    Enrollment is planned to start in February 2026.  



    Kim



  • 2.  RE: rhNGF study for NAION

    Posted 11 days ago
    Nerve growth factor (NGF) was discovered by Rita Levi-Montalcini and it won her the Nobel prize. It boosts the development and elaboration of neurons. More to the point here, it raises the threshold for apoptosis. So in the complex interplay of pro and anti-apoptotic factors, it may keep a cell alive.  So the theory is solid, but the difficulty here is in drug delivery and timing.  It cannot bring a dead cell to life.
    -Alfredo 

    Sent from my iPhone



    Original Message


  • 3.  RE: rhNGF study for NAION

    Posted 11 days ago
    If this study succeeds I guess they can also get the prize but it is a long way to go, though my hope and others , that sometimes in the future we will have a break through 



    Original Message


  • 4.  RE: rhNGF study for NAION

    Posted 11 days ago
    The Falsini group published impressive results of NGF for children with optic nerve gliomas. The initial work with NGF is pretty impressive and the trans-nasal approach may work quite well. The study is just getting off the ground.

    N



    Original Message


  • 5.  RE: rhNGF study for NAION

    Posted 11 days ago

    This is a good article showing collective use in a comprehensive manner not very recent but informative 



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  • 6.  RE: rhNGF study for NAION

    Posted 11 days ago
    Here is a short editorial that Ron Smith and I wrote, 30 years ago, for NEJM on the subject of Nerve Growth Factor:  https://pubmed.ncbi.nlm.nih.gov/9554865/

    --Alfredo



    Original Message


  • 7.  RE: rhNGF study for NAION

    Posted 11 days ago
    Sir I wanted to ask about the last words orchid editorial 
    (legacy of Levi-Montalcini) 
    Sherif 



    Original Message


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