Singman EL, Hocum B, Yohannan J, Pearson V. Fluvoxamine-associated oscillopsia and a role for personalized medication dosing. Drug Metab Pers Ther. 2015 Dec;30(4):271-5. doi: 10.1515/dmpt-2015-0006. PMID: 26351962
Original Message:
Sent: 6/29/2025 10:55:00 AM
From: Grace W Kao
Subject: RE: Nystagmus and psychiatric meds
Is the nystagmus in horizontal vector throughput the gaze ? Then this is gaze evoked nystagmus. May check any rebound nystagmus at the primary gaze , that supports vestibular cerebellar pathway dysfunction. The combination of multiple CNS action of medication is likely the cause,, may discuss with the psychiatrist to reduce some dose or taper down one or two if possible . Is any other neurological findings like tremors , gait imbalance , reduce or increase deep tendon reflexes? I may taper off LTG first . If nystagmus reduces after reducing medication , CSF study is not needed. Hope this may help . Thank you for sharing your case.
Grace Kao
Irvine , CA.
Original Message:
Sent: 6/26/2025 2:42:00 PM
From: Shruthi Harish Bindiganavile
Subject: RE: Nystagmus and psychiatric meds
Normal optic nerve , visual fields and nystagmus in primary and all gazes
Original Message:
Sent: 06-26-2025 14:27
From: Peter Savino
Subject: Nystagmus and psychiatric meds
Original Message:
Sent: 6/26/2025 12:08:00 PM
From: Shruthi Harish Bindiganavile
Subject: Nystagmus and psychiatric meds
Hello all
I have a 25 YO on long term medications for depression/ bipolar disease, most recently Lithium, lamotrigene and pregabalin, on Vyvanse for ADHD. He has many visual phenomena but is in academics and notes that he "cannot focus out of both eyes to continue to read on the computer or books". HJe has had to quit his position from this. Describes images overlap, feels his eyes move, and sees shadows to objects, colors are like "neon".
Labs for lithium and LTG levels normal, no recent changes to med dosages. We got GAD 65, paraneoplastic serum panels negative, MR brain WWO normal. Trailed Klonopin with no benefit. Exam with high frequency nystagmus in primary and all gaze, likely accoiunting for visual distortion, least in downgaze, does not have an upbeat or dowbeat pattern that I can discern at the slit lamp.
- While I think this is all likley from his multiple psych meds, is there a role in CSF testing?
- There was a remote use of Ketamine x 2 months approx 2-3 yrs ago, could that cause his visuo-perceptual issues?
- Any other meds you might try?
Thank you,
Shruthi Harish