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Nystagmus and psychiatric meds

  • 1.  Nystagmus and psychiatric meds

    Posted 06-26-2025 12:08

    Hello all

    I have a 25 YO on long term medications for depression/ bipolar disease, most recently Lithium, lamotrigene and pregabalin, on Vyvanse for ADHD. He has many visual phenomena but is in academics and notes that he "cannot focus out of both eyes to continue to read on the computer or books". HJe has had to quit his position from this. Describes images overlap, feels his eyes move, and sees shadows to objects, colors are like "neon".

    Labs for  lithium and LTG levels normal, no recent changes to med dosages. We got GAD 65, paraneoplastic serum panels negative, MR brain WWO normal. Trailed Klonopin with no benefit. Exam with high frequency nystagmus in primary and all gaze, likely accoiunting for visual distortion, least in downgaze, does not have an upbeat or dowbeat pattern that I can discern at the slit lamp.

    1. While I think this is all likley from his multiple psych meds, is there a role in CSF testing? 
    2. There was a remote use of Ketamine x 2 months approx 2-3 yrs ago, could that cause his visuo-perceptual issues?
    3. Any other meds you might try?

    Thank you,

    Shruthi Harish



  • 2.  RE: Nystagmus and psychiatric meds

    Posted 06-26-2025 14:28
    What did your exam show?
    Peter
    Sent from my iPhone





  • 3.  RE: Nystagmus and psychiatric meds

    Posted 06-26-2025 14:42

    Normal optic nerve , visual fields and nystagmus in primary and all gazes




  • 4.  RE: Nystagmus and psychiatric meds

    Posted 06-29-2025 10:55
    Is the nystagmus in horizontal vector throughput the gaze ? Then this is gaze evoked nystagmus. May check any rebound nystagmus at the primary gaze , that supports vestibular cerebellar pathway dysfunction. The combination of multiple CNS action of medication is likely the cause,, may discuss with the psychiatrist to reduce some dose or taper down one or two if possible . Is any other neurological findings like tremors , gait imbalance , reduce or increase deep tendon reflexes? I may taper off  LTG first . If nystagmus reduces after reducing medication , CSF study is not needed. Hope this may help . Thank you for sharing your case. 

    Grace Kao
    Irvine , CA. 





  • 5.  RE: Nystagmus and psychiatric meds

    Posted 06-29-2025 11:40
    Singman EL, Hocum B, Yohannan J, Pearson V. Fluvoxamine-associated oscillopsia and a role for personalized medication dosing. Drug Metab Pers Ther. 2015 Dec;30(4):271-5. doi: 10.1515/dmpt-2015-0006. PMID: 26351962



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  • 6.  RE: Nystagmus and psychiatric meds

    Posted 06-29-2025 18:45
    Was it DBN? If so, it is most likely from the lithium.
    Matt



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  • 7.  RE: Nystagmus and psychiatric meds

    Posted 06-29-2025 20:44
    Arnold Chiari can do all kinds of nystagmus would do MRI and Mrv 
    Irene
    Sent from my iPhone





  • 8.  RE: Nystagmus and psychiatric meds

    Posted 06-29-2025 20:39
    Hi may not apply in this case
    But Lithium is known IIH contributor 
    Irene Vanek
    Sent from my iPhone





  • 9.  RE: Nystagmus and psychiatric meds

    Posted 06-29-2025 23:31

    Hello,

    Lithium is the most likely culprit in my experience. This is an idiopathic reaction that can occur even at therapeutic levels of lithium. Lithium of course has significant psychiatric benefit for many patients – it can be life saving, and there isn't always a good substitute. But if there is, I would suggest stopping lithium, and hope that the patient improves.

    Best,

    Bart

     

     

    Bart K. Chwalisz, M.D.

    Neuro-ophthalmology, Headache Unit, and Skull Base Disorders Clinic. Division of  Neuroimmunology, Massachusetts General Hospital/Harvard Medical School

    https://www.massgeneral.org/neurology/treatments-and-services/inflammatory-neuroophthalmology-and-skull-base-disorders-clinic

    Neuro-ophthalmology, Massachusetts Eye & Ear Infirmary/Harvard Medical School

    Neurology, Martha's Vineyard Hospital

     

     

     






  • 10.  RE: Nystagmus and psychiatric meds

    Posted 06-30-2025 04:43
    I agree with Matt and Bart. Unfortunately, in my personal experience, even after stopping lithium completely the nystagmus often persists unabated.

    Steve Hamilton






  • 11.  RE: Nystagmus and psychiatric meds

    Posted 07-01-2025 19:40
    Discuss with psychiatrist, as the nystagmus does not always resolve with discontinuing. 
    Nothing worse than being asked to consult on your patient on the hospital in-patient psych floor and the DBN is still there (speaking from personal experience)��‍♂️����‍♂️