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56 year old male with unusual symptoms during running

  • 1.  56 year old male with unusual symptoms during running

    Posted 07-07-2025 19:46
    I have a 56 year old male with the following preconditions. 
    1. Born without an inferior vena cava, has other vasculature to compensate, however has near syncopal episodes and an occasional syncopal episode from standing from a sitting position and the doctors think he just pools his blood due to lack of IVC, and that predisposes him to these episodes.
    2. history of DVT in either leg, on blood thinners, the clots were in both iliacs at different times and the thinking was his blood just pools there and makes him susceptible to clots, he has never heard of Factor V leiden or antiphospholipid syndrome so not sure if he was tested for that
    3. recent spinal surgery for nerve root compression, unrelated to what i am going to ask
    4. prior to his spinal surgery he would have recurrent symptoms of very bright central lights in his vision in both eyes after running for about 10-15 minutes, almost always at the same location during his run. He can see peripherally but centrally it is bright, and wouldn't recognize my face or be able to read anything. If he stopped running it disappeared over a minute or so, but if he continues running it will disappear in 2 or 3 minutes, no sequelae after, no headache, weakness etc. it won't recur during the run. could  have happened 20 times by the time  he had spinal surgery. isn't back to full running again but on his treadmill at home during a run he will experience the tv looking a little squiggly for a minute or two, then back to normal

    exam shows no evidence for pigment dispersion, no transillumination defects, oct nerves are fine, visual fields done last year were normal since he has c/d ratio .6 that is unchanged over the years, iop is fine

    1. is this exercise induced migraine, even though it lasts for 2-4 minutes and doesn't recur if he continues running
    2. ?bilateral transient retinal ischemia due to his other vascular problems that may contribute to hypoperfusion
    3. occipital lobe ischemia? or seizures? vertebro-basilar insufficiency?

    since it happened so many times without any damage occurring, is it just a benign condition and nothing more to work up?

    thank you
    bob

    Robert Bellinoff, MD

    Division Head, Eye Department, Mercy Medical Group

    Site Medical Director of Midtown Medical and Surgical Specialties

     

    Mercy Medical Group

    3000 Q Street

    Sacramento, CA 95816

    (916) 733-3311 (O)

    (916) 733-3307 (F)

     

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  • 2.  RE: 56 year old male with unusual symptoms during running

    Posted 07-07-2025 20:35
    Just a thought „ I had somewhat similar patient, I thought vasospasm ended looking for patent foramen ovale transthoracic was negative but transoesophageal confirmed patent foramen ovale
    Irene Vanek
    Sent from my iPhone





  • 3.  RE: 56 year old male with unusual symptoms during running

    Posted 07-07-2025 21:07

    How is his heart? If it was his chest, arm, neck or head hurting, it would sound like an angina equivalent.

    Deb






  • 4.  RE: 56 year old male with unusual symptoms during running

    Posted 07-20-2025 21:34

     

    It appears it is bilaterally symmetric, and below may NOT be related, but ask a few more questions.

     

    See if it is truly symmetric or if one eye is affected first and then the other.

     

    And rather than being related to exercise, is it related to the brightness that occurs from being outdoors????

     

    If history is related to brightness, you may be familiar with this article:

     

    Light-induced Amaurosis: A Rare Manifestation of Internal Carotid Artery Stenosis

    Ru Jin Eugene Ting 1,Michelle Hui 2, Catherine Thoo 3, Minas T Coroneo 2, Ian C Francis 2

    Editors: Alexander Muacevic, John R Adler

    PMCID: PMC6823093  PMID: 31737459



    Likely, he has had this w/u already for carotid artery disease, but if not, you may consider it.  Could he have bilateral carotid disease, and perhaps in the setting of his venous return (not sure if venous return from head is affected???), a congenital problem , perhaps less carotid artery obstruction could more easily provoke this unusual symptom.

     

    Further, per the article, it is theorized in the setting of carotid stenosis and subsequent retinal hypoperfusion, the increase in retinal metabolism demanded by the exposure to light cannot be sustained, and this therefore manifests as light-induced amaurosis.

     

    However, it disappears as the patient continues in the light, which is what is happening in this subject.

     

    Jade

     

     

     

     

     

     

    Jade S. Schiffman MD, FAAO, FAAN

    Co-Director of Neuro-Eye Clinical Trials, Inc. 

    Co-Director Neuro-ophthalmology of Texas, P.L.L.C.

    Former Professor of Ophthalmology and Neurology, University of Texas MD Anderson Cancer Center

    Adjunct Professor, Department of Clinical Sciences, UH College of Medicine



     






  • 5.  RE: 56 year old male with unusual symptoms during running

    Posted 07-21-2025 16:52
    thank you for your thoughts, here is the update

    1. it only happened when he was running and usually appeared at the same location during the run
    2. it hasn't happened in awhile since not able to run currently, it never happened just walking into bright room or walking out doors
    3. he will check symmetry next time it happens, but seems to be symmetric and simultaneous
    4. pending labs include TEE, MRI brain, MRA head and neck with contrast
    5. hypercoagulable workup negative

    bob

    thanks for the article, i do have that in my files

    Robert Bellinoff, MD

    Division Head, Eye Department, Mercy Medical Group

    Site Medical Director of Midtown Medical and Surgical Specialties

     

    Mercy Medical Group

    3000 Q Street

    Sacramento, CA 95816

    (916) 733-3311 (O)

    (916) 733-3307 (F)

     








  • 6.  RE: 56 year old male with unusual symptoms during running

    Posted 07-22-2025 18:06
    Exercise induced migraine

    Sent via the Samsung Galaxy S23 Ultra 5G, an AT&T 5G smartphone
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  • 7.  RE: 56 year old male with unusual symptoms during running

    Posted 07-22-2025 18:08
    Ps. I had a few patients with exercise induced esotropia. We went to the racquetball court played until his symptoms started so I could get measurements. Maybe your patient's workup might benefit from a field trip. �� 

    Sent via the Samsung Galaxy S23 Ultra 5G, an AT&T 5G smartphone
    Get Outlook for Android





  • 8.  RE: 56 year old male with unusual symptoms during running

    Posted 07-23-2025 11:24
    his visual disturbance was just central bright light bilateral no zig zag or prism type visual  disturbance, no headache before or after, the bright lights lasted about two minutes if he kept running and disappeared a little sooner if he quit running

    does that still fit with exercise induced migraine?

    Robert Bellinoff, MD

    Division Head, Eye Department, Mercy Medical Group

    Site Medical Director of Midtown Medical and Surgical Specialties

     

    Mercy Medical Group

    3000 Q Street

    Sacramento, CA 95816

    (916) 733-3311 (O)

    (916) 733-3307 (F)

     








  • 9.  RE: 56 year old male with unusual symptoms during running

    Posted 07-23-2025 19:38

    I don't think this is migraine.

    Deb






  • 10.  RE: 56 year old male with unusual symptoms during running

    Posted 07-27-2025 21:06
    I have seen this twice in same age men who admitted to moderate to heavy alcohol usage.
    It would occur while on treadmill. Chiasmal vasospasm?
    Told them to decrease alcohol use and instead they decreased treadmill use!







  • 11.  RE: 56 year old male with unusual symptoms during running

    Posted 07-28-2025 19:00
    Thank you I will recheck regarding his alcohol use
    Bob






  • 12.  RE: 56 year old male with unusual symptoms during running

    Posted 07-07-2025 22:58
    I would work up thoroughly for exercise induced posterior circulation ischemia given bilateral central visual loss as migraine is certainly a diagnosis of exclusion (and most likely not the case), especially in an individual with a congenital vascular anomaly. 
    Matt


    Sent via the Samsung Galaxy S21 5G, an AT&T 5G smartphone






  • 13.  RE: 56 year old male with unusual symptoms during running

    Posted 07-08-2025 10:31
    Thank you for the suggestions. I will be pursuing those avenues. will also order a hypercoagulable panel as well. I will update you once the results come in. Appreciate your help very much.
    Bob

    Robert Bellinoff, MD

    Division Head, Eye Department, Mercy Medical Group

    Site Medical Director of Midtown Medical and Surgical Specialties

     

    Mercy Medical Group

    3000 Q Street

    Sacramento, CA 95816

    (916) 733-3311 (O)

    (916) 733-3307 (F)

     








  • 14.  RE: 56 year old male with unusual symptoms during running

    Posted 07-28-2025 18:06

    Does this man have a normal EKG? I would recommend he wear a Holter monitor or event recorder, especially during his run. I always ask myself when hearing simultaneous binocular visual loss from a patient, could this be a primary arterial "top of the basilar syndrome", a cardiac rhythm disturbance, or a combination of both?

    In 1985, a 78 yo lady began having brief, less than a minute spells of isolated total binocular BLINDNESS. She had a known, but asymptomatic RBBB on her EKG, w/o other cardiac history. I admitted her to our cardiac step-down unit. After several days of no symptoms & no arrhythmia she was discharged. The episodes returned a day or so later, She was readmitted. This time we captured multiple binocular blinding episodes during runs of 2nd degree heart block. She received a demand pacemaker. Her spells ceased. I followed her for 6 years during which she had no further "neurovascular" spells of any kind. In the last 40 years I never encountered this again & have not seen literature of similar etiology.

    Robert Saul, MD

    -------------------------------------------



  • 15.  RE: 56 year old male with unusual symptoms during running

    Posted 07-28-2025 18:59
    Thank you for that advice. I will pass it along to his provider.
    Bob